MAPT and Alzheimer disease: There are other neurodegenerative diseases with symptoms that might overlap with AD, such as frontotemporal dementia (FTD; Box 1), in which inclusions can consist of several different proteins, most typically tau (MAPT) and/or transactive response DNA-binding protein 43 (TDP-43; TARDBP); Parkinson's disease dementia (PDD; Box 1) and dementia with Lewy bodies (DLB; Box 1), in which α-synuclein inclusions represent an important part of the pathology (Box 1).