Lack of avoidance in Cacna1c+/− rats might appear surprising given the ample evidence for increased anxiety-related behavior in constitutive Cacna1c heterozygous mice (Lee et al., 2012), particularly in females (Dao et al., 2010), yet strong behavioral inhibition seen in both genotypes speaks for alterations in coping strategies rather than anxiety levels. The gene discussed is CACNA1C; the disease is Anxiety.