As a first step toward disease therapeutics and in our first direct test of the lack of product hypothesis for ALD, we fed bgm1 and dbb1 animals a diet high in medium-chain fatty acids [7% coconut oil (Birse et al., 2010)] from day 0 (d0) to day 20 (d20) post-eclosion, anticipating that bypass of the genetic block to activating long-chain FAs (LCFAs)/VLCFAs in bgm and dbb mutants via the elongase pathway might suppress neurodegeneration (Fig. 3A). Here, ACSBG1 is linked to adrenoleukodystrophy.