However, the utility of these lines as disease models is now further bolstered by their shared loss-of-function phenotype with dABCD. Moreover, it is clear that ABCD1 should be added to the growing list of human neurodegenerative-disease-related genes with functional homologs in Drosophila (Chien et al., 2002). This evidence concerns the gene ABCD1 and neurodegenerative disease.