We found that risk for AKI is increasing in octogenarians with the following risk factors: hypertension (HTN), congestive heart failure (CHF), use of angiotensin-converting enzyme (ACE) Inhibitors, use of angiotensin receptor blockers (ARBs), use of nonsteroidal anti-inflammatory drugs (NSAIDs), and exposure to contrast media. The gene discussed is ACE; the disease is acute kidney injury.