Consistently, by facilitating binding of EZH2 to its target loci, MALAT1 drives H3K27 trimethylation and repression of tumor suppressor genes or microRNAs, leading to epithelial to mesenchymal transition, migration/invastion, cell proliferation, and escape from apoptosis in several tumor types [101, 102]. The gene discussed is MALAT1; the disease is neoplasm.