All three groups of markers (1) conventional predictive markers (ER, PR, HER2, EGFR and CK5/6), (2) tumor progression markers (PTEN, PIK3CA, p53, Ki-67) and (3) stem cell markers (E-cadherin, mTOR, SOX2, SOX9, SOX10, SLUG, CD44, CD24 and TWIST) were analyzed. The gene discussed is SOX2; the disease is neoplasm.