When considering the effect of either ANGPTL4 over-expression or ANGPTL4 knock-down in tumours as diverse as hepatocellular carcinoma [17], gastric cancer [56], colorectal cancer [57, 58], squamous cell carcinoma [59], breast cancer [18] and giant cell tumour of bone [53], the presence of ANGPTL4 is described to promote the tumourigenic phenotype. The gene discussed is ANGPTL4; the disease is bone giant cell tumor.