No individual isoform of ANGPTL4 affected ALP production (data not shown) but a low concentration (25 ng/ml) of the cleaved forms of ANGPTL4 (cANGPTL4 and nANGPTL4) promoted mineralization of OSA cells (Fig. 4e, f). This evidence concerns the gene ANGPTL4 and obstructive sleep apnea syndrome.