HSPA5 and familial pancreatic carcinoma: GRP78, the regulator of the UPR, has previously been correlated with poor patient prognosis in multiple cancers, including pancreatic cancer (Avril et al., 2017; Gifford et al., 2016; Ma and Hendershot, 2004; Niu et al., 2015; Wang and Kaufman, 2014).