We evaluated associations of C17:0 and C15:0 with SNPs in the LCT, and C23:0 with SNPs in CERS4, and SPTLC3 genes, providing new insights on potential influence of adult-onset lactose intolerance and sphingolipid synthesis on circulating levels of C17:0 and C23:0 respectively. The gene discussed is SPTLC3; the disease is lactose intolerance.