We evaluated associations of C17:0 and C15:0 with SNPs in the LCT, and C23:0 with SNPs in CERS4, and SPTLC3 genes, providing new insights on potential influence of adult-onset lactose intolerance and sphingolipid synthesis on circulating levels of C17:0 and C23:0 respectively. This evidence concerns the gene CERS4 and lactose intolerance.