Subjects had a median age of 61 years (range 32–88), and included 101 males (80%), 101 individuals with hypertension (80%), 55 (38%) with diabetes, 130 (90%) with dyslipidemia or undergoing statin treatment, 109 (76%) current or former smokers (mean of 24 ± 30pack years), with an overall mean BMI of 30 ± 5.4 kg/m2, mean Hb of 138 ± 16.7 g/l and mean eGFR of 74 ± 17 ml/min/1.73 m2 (range 24–90) (Table 1). Here, GSTM1 is linked to metabolic syndrome.