Similarly, M. oleifera leaf extract was also reported to cause up-regulation of Cu/Zn superoxide dismutase (SOD), catalase (CAT) and other enzymes with antioxidant properties, thereby boosting their enzymatic activities, which in turn decreased the activities of pro-oxidant enzymes including but not limited to lipid peroxidase as observed in the cerebral cortex and hippocampal regions of AD rat model [48]. This evidence concerns the gene SOD1 and Alzheimer disease.