It is reported that levels of Pyk2 mRNA and protein and the phosphorylated PYK2 form pY881 are increased in non-small cell lung cancer (NSCLC) lesion compared with matched non-cancerous tissues, and that Pyk2 and Pyk2 pY881 are independent prognostic factors for patients with NSCLC [54]. Here, PTK2B is linked to non-small cell lung carcinoma.