GSK3B and digestive system neoplasm: They further showed that FAK and Pyk2 promoted the Wnt/β-catenin pathway by phosphorylating GSK3β(Y216), resulting in -β-catenin accumulation and its translocation from the cytoplasm to nuclei and gastrointestinal tumor formation, as Wnt-stimulated β-catenin accumulation requires Wnt-induced GSK3β/β-transducing repeats-containing proteins (β-TrCP) interaction.