In addition, ectopic expression of miR-517a and miR-517c was sufficient to inhibit cancer cell proliferation by blocking the G2/M transition, in contrast, knockdown of miR-517a and miR-517c expression in the HCC cells facilitated cell proliferation in vitro and tumor growth in vivo also through targeting Pyk2 [71]. The gene discussed is PTK2B; the disease is cancer.