It is well known that aberrant activation of Wnt/β-catenin signaling plays a critical role in colorectal carcinogenesis and progression, and a study reported that FAK/Pyk2 promotes the Wnt/β-catenin pathway and colorectal carcinogenesis via a novel FAK/PYK2/GSK3β(Y216)/β-catenin regulation axis by phosphorylating GSK3β [65]. This evidence concerns the gene PTK2B and medical procedure.