BCL11B and Huntington disease: In generating MSNs directly induced from the fibroblasts of HD patients (HD-MSN) and healthy controls, the authors used a combination of brain-enriched microRNAs (miR-9/9* and miR-124), which reconfigures chromatin accessibility [54], together with the transcription factors CTIP2, DLX1, DLX2 and MYTL1 [19,53].