As shown in Figure 4B,C, NDRG1 knockdown increased Slug, Snail, Vimentin, and N-cadherin expressions and decreased E-cadherin expression, suggesting NDRG1 knockdown triggered EMT in NPC cells, leading to the increased invasiveness shown in Figure 4A, which was also supported by the increased F-actin synthesis after NDRG1 knockdown in TW04 cells (Figure 4D). This evidence concerns the gene CDH2 and nasopharyngeal carcinoma.