FGF21 and hypertriglyceridemia: FGF21 is a key mediator of starvation that activates lipolysis in white adipose tissue (WAT) and increases fatty acid oxidation and ketogenesis in the liver [26,27] and has therapeutic effects on obesity-related metabolic disturbances such as insulin resistance, diabetes, and hypertriglyceridemia in ob/ob mice, diet-induced obese mice, and diabetic monkeys [28,29].