NPPB and chronic kidney disease: Of the studied biomarkers, NT-proBNP is produced in the ventricles after stimulusfrom the stretching of cardiac myocytes in response to cardiac wall stress.3,4 Troponin isoform I (TnI), a protein specificof the cardiac muscle, have been used as auxiliary biomarker in the diagnosis ofpathologies that involve necrosis and injury of the myocardial cells.5 Regarding cardiac tissue analysis, studiesshow that CKD patients can develop left ventricular hypertrophy (LVH) and myocardialfibrosis independent of traditional factors, with involvement of therenin-angiotensin-aldosterone system.