IL22 and inflammatory bowel disease: For example, IBD has been associated with polymorphisms in genes heavily associated with ILC3 transcription and phenotype (Rorc, Nfil3), effector function and signaling (Il22, Il23r, Il1r1, Il2ra, Il15ra, Il2, Stat5a/b) and migration (Cxcr5, Gpr183, Ccr6) [85, 87, 88].