For example, while early loss of IL-22 results in higher tumor loads in a colitis and chemical carcinogen-driven mouse model, as well as in mice with a genetic lesion in the APC tumor suppressor gene (APCmin mice) [118], neutralization of IL-22 after the peak of colitis-induced tissue damage resulted in reduced growth and proliferation of tumors [108, 118]. This evidence concerns the gene APC and colitis.