Several membrane proteins are in the 12 genes: TSPAN9 is a transmembrane protein that plays a role in the regulation of cell development, activation, growth, and motility (Protty et al. 2009), PLA2G2A is thought to participate in the regulation of the phospholipid metabolism (Kadam and Mulherkar 1999), and LYVE1 encodes an integral membrane glycoprotein that may function in lymphatic hyaluronan transport and have a role in tumor metastasis (Jackson 2003). This evidence concerns the gene PLA2G2A and neoplasm.