INS and Alzheimer disease: Moreover, insulin administration reduced pIRS1S307 level in wt mice (83.9 ± 4.9% of wt + veh, *p < 0.05; Fig. 1a, d) but not in AD mice (109.9 ± 10.6% of 3xTg + veh, p = 0.402; Fig. 1f, i).