Also, TRPV3 mutations in the linker region between S4 and S5 and in the TRP-box cause the Olmsted syndrome (congenital palmoplantar and periorificial keratoderma, alopecia, and itching), highlighting the importance of transmembrane and C-terminal domain for the function of TRP channels (Yoshioka et al. 2009; Lin et al. 2012). This evidence concerns the gene TRPV3 and Olmsted syndrome 1.