TNFSF11 and ischemia: Based on our previous finding that only endothelial and hematopoietic but not stromal precursors engraft after transplantation of unfractionated bone marrow into lethally irradiated rats [14] and mice [15] and the fact that AMG161 exclusively inhibits human but not murine RANKL, we used a reconstitution model in which we selectively exchanged the hematopoietic cell compartment to dissect the pathophysiological role of RANKL derived from hematopoietic and mesenchymal cellular sources in the development of cardiac dysfunction after ischemia.