SOAT1 and rheumatoid arthritis: Many cytokines use the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway to exert their effect in the pathology of RA, rendering them amenable to therapeutic blockade with Jakinibs which have proven effective for the treatment of RA.144 Jakinibs are being developed, and targeting STATs as well as other intracellular signaling pathways may be a future avenue for the treatment of RA, although substantial challenges remain.