CD4 effector T cells are major drivers of abnormal immunity in RA by sustaining chronic synovitis and supporting autoantibody production and a lack of reactive oxygen species could boost pro-inflammatory T cells, which shed light on the importance of energy metabolism in RA.59 As for B cells, the research focuses on their antigen presentation, antibody formation and release, and cytokine release into the milieu. Here, CD4 is linked to rheumatoid arthritis.