PRTN3 and rheumatoid arthritis: ACPAs induce NETosis and in turn NETosis provides citrullinated autoantigens.38 EBV can affect ACPA-producing B cells and impaired EBV control can be observed in RA.39 The intestinal tract is another mucosal organ implicated in the pathogenesis of RA because dysbiosis in RA patients can result from the abundance of certain rare bacterial lineages.