Indeed, the presence of local and systemic bone loss in RA patients raised the possibility that the inhibition of RANKL may be an effective strategy to limit pathologic bone resorption.141 It has been proved that combining denosumab with DMARDs may be considered for RA patients with progressive bone erosions.142 Evidence from two phase II trials and one randomized observational trial indicate that DMab inhibits focal and systemic bone loss in RA. Here, TNFSF11 is linked to rheumatoid arthritis.