TNF and rheumatoid arthritis: Other IL cytokines and their receptors have been studied as the potential target: IL-17 inhibitor (Secukinumab) was finished in a phase III study displaying improvement in patients with active RA who had an inadequate response to TNF inhibitors.139 However, IL-12/23 blockade, ustekinumab, did not see satisfying outcomes despite being combined with MTX in a randomized phase II study.140 The drugs targeting IL-7, 15, 18, 21, 32, and 33 are also in a clinical trial.