On the other hand, sex dependence in human was found in few other studies: Fava et al. [20] found that V433M mutation in CYP4F2 gene was associated with cerebral infarction in male patients and the study [31] based on Japanese population found that G allele at rs2108622 was more frequent in male patients than in the controls. This evidence concerns the gene CYP4F2 and brain infarction.