In CRC and hepatocellular carcinoma (HCC), zinc finger antisense 1 (ZFAS1) destabilizes p53 to modulate CDK1 and the expression of its partner, cyclin B1, thus facilitating the G1/S transition, while highly upregulated in liver cancer (HULC) represses its neighboring eukaryotic translation elongation factor 1 epsilon 1 (EEF1E), which is a pivotal p53 activator and this mechanism promotestumor cell growth47,48. The gene discussed is ZFAS1; the disease is hepatocellular carcinoma.