Broader MCPs contained genes with reduced penetrance for ovarian cancer risk compared with BRCA1 and BRCA2, including the mismatch repair (MMR) genes (MIM: 120436, 609309, 600678, 600259) associated with Lynch syndrome (hereditary non-polyposis colorectal cancer, HNPCC [MIM: 609310, 120435, 614350, 614337]) and other genes involved in the homologous recombination pathway. The gene discussed is BRCA1; the disease is ovarian cancer.