In contrast, more ε4 alleles were associated with more pathology and more severe dementia.23 Mino, et al. showed that there was no statistically significant relationship between case group (with AD and dementia) and control group (without AD and dementia) in terms of sex and family history and distribution of ApoE alleles.24 A study conducted in 2014 reported that there is a statistically significant relationship between the types of ApoE and patients’ age so that risk alleles, such as ε4, decrease the age of onset as 3-6 months.5 This evidence concerns the gene APOE and Alzheimer disease.