More recently, another study using the same model of acetic acid-induced colitis in rats showed that the hydroalcoholic extract of Brazilian red propolis attenuated colitis, an effect associated with decreases in myeloperoxidase (MPO) activity, gross, and histological scores of tissue damage and the inducible isoform of nitric oxide synthase (iNOS) expression [60]. Here, NOS2 is linked to colitis.