TNFSF10 and malignant colon neoplasm: Kaempferol is another flavonoid ingredient of propolis inducing apoptosis through activation of TNF-related apoptosis-inducing ligand (TRAIL) in SW480 cells, a human colon cancer [127], and inhibiting ribosomal protein S6 kinase (RSK2) and mitogen- and stress-activated kinase (MSK1), main regulators in tumor promoter induced cell transformation [128].