Based on these researches demonstrating the role of IL-33 on tumor cells, as well as the similarity between tumor cells and trophoblast cells, we hypothesise that IL-33/ST2/IL-1 R4 will be associated with the function of trophoblast cells which may explain an association between IL-33/ST2/IL-1 R4 and PE. The gene discussed is IL33; the disease is neoplasm.