TP53 and neoplasm: To study the effect of combining Cpd-5 and a taxane in promoting tumour regression, we transplanted FVB/NrJ wild-type mice with K14cre;BRCA1−/−;TP53−/− tumours39 and treated the tumours with vehicle, 5 or 10 mg/kg of Cpd-5, 12.5 or 25 mg/kg of docetaxel, 25 mg/kg of docetaxel with 5 mg/kg of Cpd-5 or 12.5 mg/kg of docetaxel with 10 mg/kg Cpd-5 (Fig. 3a).