In this study, a possible oncojanus role of nuclear CI genes is proposed, as an overall poor prognosis in a big cohort of NSCLC patients was associated with the combination of low NDUFS1 and high NDUFS8 expression levels, while the opposite phenotype (high NDUFS1 and low NDUFS8) seemed to have a protective effect. Here, NDUFS8 is linked to non-small cell lung carcinoma.