HOX11 (TLX1), similar to other HOXA subgroups including HOX11L2 (TLX3), is an oncogene that induces T-cell acute lymphoblastic leukemia (T-ALL) by chromosomal translocation of t(10;14)(q24;q11) and t(7;10)(q35;q24) [143]. Here, TLX3 is linked to T-cell acute lymphoblastic leukemia.