Peng et al. showed that DNMTi 5-aza-2′deoxycytidine (5AZAdC) can up-regulate tumor production of Th1-type chemokines CXCL9 and CXCL10 to increase effector T cell infiltration into TME and improve therapeutic response to PD-L1 blockade compared to PD-L1 blockade alone [52]. This evidence concerns the gene CD274 and neoplasm.