To address this conundrum, the effects of two AHR agonists, 3,3′-diindolylmethane (DIM) and 2,3,7,8-tetrachloridibenzo-p-dioxin (TCDD), on cancer cell colony morphology (Matrigel), migration (scratch assay), and/or metastasis (zebrafish assay) were determined as for AHR antagonists. This evidence concerns the gene AHR and cancer.