Therefore, we used multiple complementary molecular and pharmacological approaches to confirm that inhibition of AHR activity suppresses aggressive tumor behavior, as defined here by a reduction in irregular colony growth in 3D Matrigel cultures, migration rate across a monolayer scratch wound, and metastasis in a zebrafish xenograft model, and to determine the effects of exogenous AHR agonists in a head-to-head comparison with the same readouts. This evidence concerns the gene AHR and neoplasm.