NGLY1 and cancer: In fact, they showed that chemical inhibition of NGLY1 function potentiates cytotoxicity caused by proteasome inhibition in human cancer cell lines (Tomlin et al. 2017), which mirrors the observation in nematodes that png-1 loss-of-function mutants are extremely hypersensitive to proteasome inhibition by bortezomib (Lehrbach and Ruvkun 2016).