In fact, the loss of each S. Typhimurium Tol-Pal protein impacted Rcs signaling activity, cell morphology, Rif resistance, and survival during bacteremia, including loss of YbgC and CpoB, whose biological relationship with Tol-Pal was unresolved (Fig. 2A, 4A and B, and 6A and B). This evidence concerns the gene ARPP21 and bacterial infectious disease with sepsis.