YAP1 and cancer: Another recent work showed that rottlerin, a natural polyphenolic compound derived from Mallotus philipinensis, exhibits antitumor activity in NSCLC cells (inhibits cancer cell proliferation, migration, and invasion, and enhances cell cycle arrest and apoptosis) partly through the inhibition of oncogenic TAZ [196], supporting the intriguing possibility to use natural compounds in order to inhibit oncogenic YAP and/or TAZ function.