Ras-association domain family 1 isoform A (RASSF1A), which activates MST1/2 and LATS1 in the presence of DNA damage or other stress signals [114,115,116], is epigenetically inactivated on its promoter in 40% of primary NSCLC [117,118,119]. Here, LATS1 is linked to non-small cell lung carcinoma.