However, much of the literature reports evidence of the oncogenic role of YAP and TAZ in NSCLC which will be the focus of our review; meanwhile, we will keep in mind the opposite role of YAP and TAZ observed in SCLC compared to NSCLC that become clinically relevant when NSCLC is transformed into SCLC and needs different therapeutic treatments [71]. This evidence concerns the gene YAP1 and small cell lung carcinoma.