YAP1 and Familial prostate cancer: For example, in murine models of prostate cancer, YAP1 has been shown to promote the transcription of Cxcl5, a chemochine which attracts myeloid-derived suppressor cells (MDSCs) to the tumor microenvironment, reducing the immune anti-tumor response, and the knock-down of YAP1 reduced MDSCs in the intratumoral population of immune cells, impairing tumor progression [230].