Among YAP/TAZ endogenous inhibitors, it has been shown that LATS2 is mutated or more frequently downregulated in NSCLC through multiple mechanisms such as promoter hypermethylation, or recruitment of repressive epigenetic complexes including long noncoding RNAs and repressive Enhancer of Zeste Homolog 2 (EZH2) [103,104,105,106,107]. This evidence concerns the gene LATS2 and non-small cell lung carcinoma.