KRAS and neoplasm: TAZ overexpression in normal bronchial epithelial cells was found to be sufficient to promote tumor formation when injected into nude mice in one study [80] and not in another study which used a different cell line [78], while overexpression of YAP alone was not able to induce de novo tumor formation but only to promote progression of tumors driven by Kirsten RAt Sarcoma (KRAS) or Liver Kinase B1 (LKB1) mutations in mice [82,83].