TINF2 and hypotrichosis 1: Patients with DC or HHS carry mutations in genes encoding proteins of the telomerase complex (DKC1, NHP2, NOP10, TERC, TERT) or required for its assembly (WRAP53), components of the shelterin complex (ACD, TINF2) as well as other telomere regulators (CTC1, PARN, RTEL1, and possibly NAF1 and STN1) [47].