PGR and neoplasm: Furthermore, CD146 expression has been associated with high grade tumors, estrogen receptor (ER)- and progesterone receptor (PR)-negative tumors and the triple-negative subtype (ER-/PR-/ human epidermal growth factor receptor 2 (HER2)-) [3,5,19] while downmodulation of CD146 leads to a less aggressive phenotype tumor [19].