As shown in Figure 6A, the expression of cleaved caspase-3 (17 kDa large subunit), cleaved caspase-9 (37 kDa large subunit), and cleaved PARP (89 kDa carboxyterminal catalytic domain) was increased in bornyl cis-4-hydroxycinnamate-treated A2058 and A375 melanoma cells, while the levels of pro-caspase-3 and pro-caspase-9 were decreased after bornyl cis-4-hydroxycinnamate treatment; the expression levels of caspase-8 were unchanged. This evidence concerns the gene CASP8 and melanoma.