The molecular mechanism involved in bornyl cis-4-hydroxycinnamate-induced apoptosis in A375 melanoma cells was elucidated from proteomic data, which showed significant changes in the expression of several crucial proteins, including sodium/potassium-transporting ATPase subunit α-1, ATP synthase subunit β, prohibitin, stress 70 protein, dihydrolipoyl dehydrogenase, and 3-hydroxyacyl-CoA dehydrogenase type-2, which are associated with mitochondrial function or apoptosis in melanoma cells. Here, PHB1 is linked to melanoma.