A study carried by Dominguez-Avila et al. [37], fed young male Wistar rats (148 g BW) for 9 weeks with a control diet (3.6 kcal/g; 25.3% from fat) and a HF-diet (4.5 kcal/g; 54.8% from fat), and results showed a lower food intake, higher plasma leptin levels, higher body and hepatic fat content with mild or no lipidemic modifications (TC, HDL-C, TAG, low-density lipoprotein cholesterol (LDL-C)) in the HF group, similar to our findings for the HF and control groups. Here, LEP is linked to hydrops fetalis.