The CXCL5/CXCR2 axis contributes to the induction of epithelial–mesenchymal transition (EMT) and the migration and invasive ability of HCC cells via activating the PI3K/Akt/GSK-3β/Snail and PI3K/Akt/ERK1/2 signaling pathways [16,17]. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.