The phosphatidylinositol-3-kinases-protein/kinase B (PI3K/Akt) pathway is a main survival pathway, the MEK–MAPK pathway regulates proliferation and migration, and the Src-suppressed C kinase substrate (SSeCKS) pathway mediates vasopermeability, all of which are important effects of VEGF-A in stroke. The gene discussed is VEGFA; the disease is stroke disorder.