Its ability to do so is linked to two of its T1SS effectors, Ank1 and Ank6, which phenocopy p65 inhibition observed during infection and do so by not only binding p65 but also by exploiting importin β1 and exportin 1, host proteins that are essential for transporting cargo into and out of the nucleus, respectively [31, 32]. This evidence concerns the gene ANK1 and infection.