CD2AP and infection: To determine whether enhanced TFH differentiation seen in CD2AP deficiency had an impact on antiviral antibody-mediated immunity, we utilized the LCMV-clone13 (LCMV-c13) model of chronic viral infection since TFH-dependent high affinity antibody responses in the GCs and class-switch recombination to IgG2a/2c subclasses are required for control of the infection [19–21].