CD4 and infection: Consistent with the accelerated clearance of LCMV, the frequencies and numbers of total and LCMV gp-specific TFH cells in the spleen 22 days after infection were significantly increased (Fig 3B and 3D; S3B and S3C Fig), although total numbers of LCMV-specific CD4 T cells were not changed in Cd4-cre+Cd2apF/F mice compared to control mice (Fig 3D).