Within the same clusters, the most over-represented DNA binding motifs included those for CAR (Constitutive Androstane Receptor, encoded by Nr1i3), AHR (Aryl Hydrocarbon Receptor) and its dimerization partner ARNT (AHR Nuclear Translocator), three TFs significantly overexpressed at the HCC stage (S2 Table). This evidence concerns the gene ARNT and hepatocellular carcinoma.