Multiple molecular pathways are investigated in the occurrence and development of HCC, such as vascular endothelial growth factor receptor(VEGFR), epidermal growth factor receptor (EGFR), extracellular signal‐regulated kinase 1/ 2(ERK1/2) and phosphoinositide 3‐kinase / protein kinase B(PI3K/AKT)pathway 5, 6, 7. This evidence concerns the gene AKT1 and hepatocellular carcinoma.