RB1 and neuroendocrine carcinoma: 20 examined 25 colorectal NECs and concluded that the molecular features of colorectal NECs are similar to those of adenocarcinomas, not NETs, and hypothesized that Rb‐p16 pathway disruption may contribute to the promotion of proliferative activity in colorectal NECs. Additionally, ENETS updated the guidelines separating WHO G3 into G3 NET and G3 NEC, which stated that G3 NET and G3 NEC showed different characteristics and prognoses 1.