MMP16 and malignant glioma: For example, our previous study confirmed that MMP2 is required for the MMP16‐mediated migratory and invasive phenotype of GBM.25 In the present study, our results determined that GCN5 knockdown significantly attenuated the promoting effects of HMGA2 on GBM cell migration and invasion, which further verified that the HMGA2/GCN5 heterodimer interaction promoted malignant glioma invasion through direct activation of MMP2 gene expression (Figure 7H).