HMGA2 also induced a chromatin conformational change in the promoter region of matrix metalloproteinase 2 (MMP2), a well‐documented extracellular matrix regulator20, 21 and invasion factor.21, 22, 23 HMGA2 recruited the enhancer complex to transcription start site (TSS) of MMP2 and promoted the gene expression and invasion phenotype of GBM cells. This evidence concerns the gene MMP2 and glioblastoma.