Previous results showed that HMGA2 may regulate the expression of histone acetyltransferases (Hats) in pancreatic ductal adenocarcinoma.26 Our results showed that HMGA2 interacts with GCN5, the first identified histone lysine acetyltransferase, and recruits GCN5 to certain regions of the MMP2 promoter. Here, HMGA2 is linked to pancreatic ductal adenocarcinoma.