H. Cornils reported that NDR1 ablation in mice is associated with the development of T‐cell lymphoma.36 Results of microarray in many human cancers also displayed that NDR1 was decreased compared with their corresponding normal tissues, such as gastric cancer,37 skin cancer,38 acute lymphoblastic leukemia,39 and prostate cancer.13, 14, 15, 16 Conversely, opposite result was found in breast cancer.9 Collectively, notion that NDR1 acts as tumor suppressor protein has been strengthened in most though few reports, so as our result. This evidence concerns the gene STK38 and prostate cancer.