Some studies indicate that NDR1 acts as a proto‐oncogene in progressive ductal carcinoma in situ,9 lung adenocarcinoma,10, 11 and ovarian cancer.12 On the contrary, NDR1 mRNA has been reported downregulated in samples of patients suffering from prostate cancer.13, 14, 15, 16 Likewise, some animal experiments suggest that mammalian NDR1 has a role as a tumor suppressor protein (Cornils, H., Stegert, M.R., Dirnhofer, S., and Hemmings, B.A., unpublished data).17 Recent studies reveal that NDR1 is a member of the mammalian Hippo pathway,18 which usually been known as a tumor suppressor pathway.19 The gene discussed is STK38; the disease is Familial prostate cancer.