Actually, the replacement of some epithelial markers (like E‐cadherin) by mesenchymal markers (Snail, Slug, Twist1, Zeb1/2) during prostate cancer formation and metastasis has already been reported.21, 22, 23, 24 As an important process of cancer metastasis, EMT has more or less relationship with various signaling pathway, such as Wnt, TGF‐β, Notch, and Hippo signal pathway.25, 26, 27, 28 Therefore, we speculate that NDR1 may play a role in prostate cancer progression by affecting on EMT. The gene discussed is TWIST1; the disease is prostate cancer.