According to previous studies, we chosen and analyzed 6 major cell signaling pathways (MAPK, HIPPO, PI3K‐Akt, NOTCH, WNT and NF‐κB), which are altered during the development and progression of prostate cancer.32, 33 In particular, we put our sight on molecular in Hippo pathway due to the remarkable difference between the 2 cell types and less related study available. The gene discussed is AKT1; the disease is Familial prostate cancer.