For instance, a focal amplification on chromosome 11q13 (FGF19 and CCND1) and overexpression of the FGF19 gene has been identified in a subset of HCCs, and multiple studies have demonstrated the roles of the FGF19–FGFR4 axis in HCC 17, 18, 19, 20. Here, FGFR4 is linked to hepatocellular carcinoma.